Which enzyme is involved in the pathogenesis of gout, and what is its role?

A Xanthine oxidase, which catalyzes the conversion of hypoxanthine to xanthine ✓
B Uricase, which breaks down uric acid to allantoin
C Aldehyde dehydrogenase, which metabolizes aldehydes to carboxylic acids
D Glutathione peroxidase, which reduces oxidative stress

Explanation

Xanthine oxidase is an enzyme involved in the pathogenesis of gout. It catalyzes the conversion of hypoxanthine to xanthine, and then xanthine to uric acid, leading to hyperuricemia and the formation of urate crystals.

Source

Medical Biochemistry textbook
Enzymes in Disease Biochemistry Purine Metabolism Disorders Medium MEDICAL Confidence: high