Which of the following types of protein degradation is characterized by the targeting of proteins with specific amino-terminal residues?

A Ubiquitin-proteasome pathway
B Lysosomal degradation
C N-end rule pathway ✓
D Caspase-mediated degradation

Explanation

The N-end rule pathway is a type of protein degradation that targets proteins with specific amino-terminal residues, such as arginine, lysine, and leucine.

Source

Varshavsky, A. (2019). N-end rule: a model for understanding the intricacies of protein degradation. Journal of Biological Chemistry, 294(15), 5373-5385.
Protein Metabolism Biochemistry Protein Degradation Hard MEDICAL Confidence: high