Which enzyme deficiency is associated with an increased risk of atherosclerosis due to elevated levels of homocysteine?

A Cystathionine beta-synthase
B Methionine synthase
C Methylenetetrahydrofolate reductase (MTHFR) ✓
D Dihydrofolate reductase

Explanation

MTHFR is an enzyme that plays a crucial role in the metabolism of homocysteine. A deficiency in MTHFR can lead to elevated levels of homocysteine, which is a risk factor for atherosclerosis.

Source

Clinical Biochemistry
Enzymes in Disease Biochemistry Amino Acid Metabolism Disorders Hard MEDICAL Confidence: high