What is the primary mechanism by which very-low-density lipoproteins (VLDLs) are converted to low-density lipoproteins (LDLs) in the bloodstream?

A Hydrolysis by lipoprotein lipase
B Lipid transfer mediated by phospholipid transfer protein
C ApoC-II mediated activation of lipoprotein lipase
D Sequential loss of triglycerides and acquisition of cholesterol esters ✓

Explanation

VLDLs are converted to LDLs through the sequential loss of triglycerides and the acquisition of cholesterol esters, a process mediated by the action of lipoprotein lipase and other factors.

Source

Lehninger Principles of Biochemistry
Lipid Metabolism Biochemistry Lipoprotein Metabolism Medium MEDICAL Confidence: high