Which enzyme is involved in the metabolism of homocysteine and its deficiency can lead to hyperhomocysteinemia, a risk factor for cardiovascular disease?

A Methionine synthase
B Cystathionine beta-synthase
C Methylenetetrahydrofolate reductase ✓
D Betaine-homocysteine methyltransferase

Explanation

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role in the metabolism of homocysteine, and its deficiency can lead to hyperhomocysteinemia.

Source

American Heart Association (AHA)
Enzymes in Disease Cardiovascular Disease Homocysteine Metabolism Medium MEDICAL Confidence: high