What is the primary enzyme deficiency responsible for the development of Pompe disease, a genetic disorder characterized by the accumulation of glycogen in muscles?

A Acid alpha-glucosidase ✓
B Alpha-amylase
C Glucosidase II
D Debranching enzyme

Explanation

Pompe disease is caused by a deficiency of acid alpha-glucosidase, an enzyme that breaks down glycogen in lysosomes.

Source

National Institutes of Health (NIH)
Enzymes in Disease Genetic Disorders Lysosomal Storage Diseases Hard MEDICAL Confidence: high