What is the role of enzyme replacement therapy in the management of Gaucher's disease?

A To reduce the levels of glucocerebrosidase
B To increase the levels of glucocerebrosidase ✓
C To inhibit the activity of glucocerebrosidase
D To enhance the degradation of glycolipids

Explanation

Gaucher's disease is caused by a deficiency of the enzyme glucocerebrosidase, which leads to an accumulation of glycolipids in cells. Enzyme replacement therapy involves administering recombinant glucocerebrosidase to increase its levels and restore normal cellular function.

Source

NCBI Bookshelf: Gaucher Disease
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high