What is the primary cause of lactic acidosis in patients with uncontrolled type 2 diabetes?

A Increased glucose production in the liver
B Impaired glucose uptake in skeletal muscle
C Enhanced glycolysis due to insulin deficiency ✓
D Reduced activity of the enzyme pyruvate dehydrogenase

Explanation

In uncontrolled type 2 diabetes, the lack of insulin leads to increased glucose levels, which in turn causes an increase in glycolysis. This results in an accumulation of lactic acid, leading to lactic acidosis.

Source

Harrison's Principles of Internal Medicine
Metabolic and Nutritional Disorders Diabetes Mellitus Complications of Diabetes Medium MEDICAL Confidence: high