Which of the following types of protein degradation is characterized by the involvement of ubiquitin and the 26S proteasome?

A Autophagy
B Proteolysis by lysosomal enzymes
C Ubiquitin-proteasome pathway ✓
D Calpain-mediated proteolysis

Explanation

The ubiquitin-proteasome pathway is a major route for protein degradation, where ubiquitin tags target proteins for degradation by the 26S proteasome.

Source

Lodish et al., Molecular Cell Biology
Protein Metabolism Biochemistry Protein Degradation Hard MEDICAL Confidence: high