What is the primary cause of lactic acidosis in patients with uncontrolled type 1 diabetes?

A Impaired glucose uptake in muscles
B Increased glucose production in the liver ✓
C Defective pyruvate dehydrogenase enzyme
D Excessive fatty acid oxidation

Explanation

In uncontrolled type 1 diabetes, the liver produces excessive glucose due to lack of insulin, leading to increased production of lactic acid.

Source

Harrison's Principles of Internal Medicine
Metabolic and Nutritional Disorders Diabetes Mellitus Diabetic Ketoacidosis and Lactic Acidosis Medium MEDICAL Confidence: high