Which of the following metabolic disorders is characterized by an accumulation of very-long-chain fatty acids in tissues due to a deficiency in the enzyme peroxisomal acyl-CoA oxidase?

A Zellweger syndrome
B Refsum disease
C Adrenoleukodystrophy ✓
D Rhizomelic chondrodysplasia punctata

Explanation

Adrenoleukodystrophy is a metabolic disorder caused by mutations in the ABCD1 gene, leading to a deficiency in peroxisomal acyl-CoA oxidase and subsequent accumulation of very-long-chain fatty acids.

Source

Orphanet Journal of Rare Diseases
Metabolic and Nutritional Disorders Genetic Disorders Peroxisomal Disorders Medium MEDICAL Confidence: high