Which of the following proteins is responsible for regulating protein degradation through the ubiquitin-proteasome pathway?

The ubiquitin-proteasome pathway is a major mechanism for regulating protein degradation, and all of the above proteins play a crucial role in this process. Ubiquitin tags proteins for degradation, proteasome is the proteolytic complex that degrades proteins, and E3 ubiquitin ligase is the enzyme that catalyzes the transfer of ubiquitin to target proteins.