What is the primary enzyme responsible for the breakdown of glycogen to glucose in the liver, and its deficiency leads to Glycogen Storage Disease Type I?

A Glucose-6-phosphatase ✓
B Phosphofructokinase
C Amylase
D Debranching enzyme

Explanation

Glucose-6-phosphatase is the enzyme responsible for converting glucose-6-phosphate to glucose in the liver, and its deficiency leads to Glycogen Storage Disease Type I, also known as von Gierke's disease.

Mnemonic

G-6-P = Glucose-6-phosphatase, '6' reminds 'sixth' step in glycolysis

Source

Harper's Biochemistry
Enzymes in Disease Biochemistry Glycogen Metabolism Disorders Medium MEDICAL Confidence: high