What is the primary enzyme responsible for the breakdown of phenylalanine in the body, and its deficiency leads to Phenylketonuria?

A Phenylalanine hydroxylase ✓
B Tyrosinase
C Homogentisate 1,2-dioxygenase
D Cystathionine beta-synthase

Explanation

Phenylalanine hydroxylase is the enzyme responsible for converting phenylalanine to tyrosine. A deficiency in this enzyme leads to the accumulation of phenylalanine, causing Phenylketonuria.

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Amino Acid Metabolism Disorders Medium MEDICAL Confidence: high