What is the role of enzyme lysosomal acid lipase in the human body, and what disease is caused by its deficiency?

A Breakdown of glycogen and causes Pompe disease
B Breakdown of lipids and causes Wolman disease ✓
C Synthesis of cholesterol and causes Smith-Lemli-Opitz syndrome
D Degradation of proteins and causes Tay-Sachs disease

Explanation

Lysosomal acid lipase is an enzyme responsible for breaking down lipids in the lysosomes. Its deficiency leads to the accumulation of lipids, causing Wolman disease.

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high