Which of the following metabolic disorders is characterized by the accumulation of very-long-chain fatty acids in the brain and other tissues?

A Phenylketonuria
B Tay-Sachs disease
C Adrenoleukodystrophy ✓
D Gaucher's disease

Explanation

Adrenoleukodystrophy is a genetic disorder that affects the breakdown of very-long-chain fatty acids, leading to their accumulation in the brain and other tissues.

Mnemonic

_ALD = Accumulation Leads to Damage

Source

National Institute of Neurological Disorders and Stroke
Metabolic and Nutritional Disorders Lipid Metabolism Fatty Acid Metabolism Medium MEDICAL Confidence: high