What is the role of the enzyme glucocerebrosidase in the human body, and what disease is caused by its deficiency?

A Breakdown of glycogen, causing Pompe disease
B Breakdown of glucocerebroside, causing Gaucher's disease ✓
C Synthesis of glucose, causing Diabetes
D Degradation of proteins, causing Muscular dystrophy

Explanation

Glucocerebrosidase is an enzyme involved in the breakdown of glucocerebroside, a glycolipid. Deficiency of this enzyme leads to Gaucher's disease, a genetic disorder characterized by the accumulation of glucocerebroside in cells.

Mnemonic

Glucose + cerebroside = Gaucher's

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high