Which enzyme is involved in the breakdown of homogentisic acid, and its deficiency leads to alkaptonuria, a rare genetic disorder characterized by darkening of the skin and connective tissue?
Explanation
Alkaptonuria is caused by a deficiency of the enzyme homogentisate 1,2-dioxygenase, which is responsible for breaking down homogentisic acid.
Source
NCERT Class 12 Biochemistry