What is the relationship between the enzyme acid alpha-glucosidase and the disease Pompe?

A Deficiency of acid alpha-glucosidase leads to increased glycogen storage in muscles ✓
B Excess of acid alpha-glucosidase leads to decreased glycogen storage in muscles
C Deficiency of acid alpha-glucosidase has no effect on glycogen storage in muscles
D Excess of acid alpha-glucosidase leads to increased glycogen storage in liver

Explanation

Pompe disease, also known as glycogen storage disease type II, is caused by a deficiency of the enzyme acid alpha-glucosidase, leading to accumulation of glycogen in muscles.

Source

OMIM (Online Mendelian Inheritance in Man)
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high