What is the role of the enzyme Alpha-Galactosidase in the treatment of Fabry disease, a genetic disorder caused by the accumulation of globotriaosylceramide?

A Breaking down globotriaosylceramide ✓
B Synthesizing globotriaosylceramide
C Regulating the expression of genes involved in glycosphingolipid metabolism
D Inhibiting the activity of lysosomal enzymes

Explanation

Alpha-Galactosidase is the enzyme responsible for breaking down globotriaosylceramide. In Fabry disease, a deficiency in this enzyme leads to the accumulation of globotriaosylceramide, causing various symptoms. Enzyme replacement therapy with Alpha-Galactosidase can help alleviate these symptoms.

Source

Orphanet Journal of Rare Diseases
Enzymes in Disease Biochemistry Lysosomal Storage Disorders Hard MEDICAL Confidence: high