Which of the following buffers is primarily responsible for maintaining acid-base balance in the extracellular fluid?

A Phosphate buffer
B Bicarbonate buffer ✓
C Protein buffer
D Hemoglobin buffer

Explanation

The bicarbonate buffer system is the primary buffer system responsible for maintaining acid-base balance in the extracellular fluid, including the blood.

Mnemonic

Bi-carbonate = two-carbon → two components (HCO3- and H2CO3) work together to maintain balance

Source

Berne and Levy Physiology
Electrolytes and Acid-Base Balance Physiology Acid-Base Balance Easy NURSING Confidence: high