Which lysosomal storage disease is caused by the deficiency of the enzyme alpha-galactosidase A, leading to the accumulation of globotriaosylceramide?

A Gaucher's disease
B Fabry disease ✓
C Niemann-Pick disease
D Tay-Sachs disease

Explanation

Fabry disease is a lysosomal storage disease caused by the deficiency of alpha-galactosidase A, leading to the accumulation of globotriaosylceramide.

Mnemonic

Fab = Father And Brother, affected in Fabry disease

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Hard NURSING Confidence: high