Which enzyme's dysfunction is associated with an increased risk of developing hyperhomocysteinemia, a condition linked to cardiovascular disease?

A Methionine synthase
B Cystathionine beta-synthase
C Methylenetetrahydrofolate reductase ✓
D Homocysteine thiolactone hydrolase

Explanation

Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the remethylation of homocysteine to methionine. Dysfunction or deficiency in MTHFR can lead to elevated homocysteine levels, increasing the risk of cardiovascular disease.

Source

American Journal of Clinical Nutrition
Enzymes in Disease Biochemistry One-Carbon Metabolism Hard NURSING Confidence: high