MedicoInfo-04

ABO Blood Group System & It’s Determination

The Human ‘ABO’ Blood Group System discovered by Landsteiner’s in 1901. The principle of Blood grouping is based on the Landsteiner’s Law. Landsteiner’s Law : “The corresponding antibody is never present in the serum of an individual when the antigen is manifest on his red cells”. (Same type of antigen and antibody cannot stay together in an individual). ‘ABO’ Blood group system is divided into four major groups and they are ‘A’ group, ‘B’ group, ‘AB’ group and ‘O’ group. This depends on the presence of ‘A’ antigen or/and ‘B’ antigen on the surface of the Red Blood Corpuscles (RBCs) and determined by agglutination reactions obtained by mixing their Red blood cells with two different reagents (corresponding antibodies), known as Anti-A and Anti-B. The percentage of different group in Indian and Caucasian (US) population as approximately as follows : ‘ABO’ Group is determined by two methods : Forward Grouping Reverse Read More

MedicoInfo-04

Human Blood Group System

The basis of human blood group system is the antigenic character of the Red cells. Red blood cell of the human being contains lipoprotein or glycoprotein on their surface which constitute the blood group antigens. About 300 blood group system so far discovered and some of the more common are____ Natural           : ABO (A, B) MNS (M, N, S,s) P (P­1, P, PK,P) Lewis (Lea, Leb) Luthern (Lua, Lub) Ii (I, i) etc. Immune          : Rhesus (C, c, D, d, E,e) Kidd (JKa, JKb) Duffy (Fya, Fyb) Kell (K, k, Kpa, kpb, Jsa, Jsb) etc. Of these only two blood group system ; ‘ABO’ and ‘Rhesus’ are of major clinical importance and constitute major antigens. Which causes serious complication in blood transfusion, hence they may be tested whenever blood is administrated. The other blood group systems are of less importance because the red cell antigens are weak and naturally occurring Read More